Early life stress enhancement of limbic epileptogenesis in adult rats: Mechanistic insights

G Kumar; NC Jones; MJ Morris; S Rees; TJ O'Brien; MR Salzberg

Journal article

Early life stress enhancement of limbic epileptogenesis in adult rats: Mechanistic insights

G Kumar, NC Jones, MJ Morris, S Rees, TJ O'Brien, MR Salzberg

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011

DOI: 10.1371/journal.pone.0024033

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Abstract

Background: Exposure to early postnatal stress is known to hasten the progression of kindling epileptogenesis in adult rats. Despite the significance of this for understanding mesial temporal lobe epilepsy (MTLE) and its associated psychopathology, research findings regarding underlying mechanisms are sparse. Of several possibilities, one important candidate mechanism is early life 'programming' of the hypothalamic-pituitary-adrenal (HPA) axis by postnatal stress. Elevated corticosterone (CORT) in turn has consequences for neurogenesis and cell death relevant to epileptogenesis. Here we tested the hypotheses that MS would augment seizure-related corticosterone (CORT) release and enhance neur..

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University of Melbourne Researchers

Nigel Jones Author

Sandra Rees Author

Michael Salzberg Author

Related Projects (2)

The Effect of Stress and Hypercortisolaemia on Limbic Epileptogenesis & Affective Disorder.

This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxi..

Stress and epilepsy

High rates of anxiety and depression occur in individuals with temporal lobe epilepsy (TLE), the most common form of focal epilepsy in adult..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was funded by Australian National Health and Medical Research Council Project Grants #566843 and #400088 (http://www.nhmrc.gov.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.